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DIAMOND Trial Information

DIAMOND Trial Information Participant Information Recruitment Participating Hospitals Documents

Recruitment for the DIAMOND trial was completed in 2022 with 2-year follow-up completed in 2024.

Primary Outcome Publication:

Alexander Tanith, Asadi Sharin, Meyer Michael, Harding Jane E., Jiang Yannan, Alsweiler Jane M., Muelbert Mariana, & Bloomfield Frank H. (2024). Nutritional Support for Moderate-to-Late–Preterm Infants—A Randomized Trial. New England Journal of Medicine, 390(16), 1493–1504. https://doi.org/10.1056/NEJMoa2313942

 

Publications arising from the DIAMOND trial:

Bloomfield FH, Harding JE, Meyer MP, Alsweiler JM, Jiang Y, Wall CR, Alexander T on behalf of the DIAMOND study group. ‘The DIAMOND trial – DIfferent Approaches to MOderate and late preterm Nutrition: Determinants of feed tolerance, body composition and development: protocol of a randomised trial.’ BMC Paediatrics 2018; 18(1): 220. doi:0.1186/s12887-018-1195-7

 

GALANTE, L., VICKERS, M.H., MILAN, A.M., REYNOLDS, C.M., ALEXANDER, A., BLOOMFIELD, F.H., PUNDIR, S. ‘Feasibility of standardized human milk collection in neonatal care units.’ Scientific Reports 2019. 9, Article number: 14343. Doi: https://doi.org/10.1038/s41598-019-50560-y

 

ASADI, S., BLOOMFIELD, F.H., ALEXANDER, T., MCKINLAY, C.J.D., RUSH, E.C., HARDING, J.E. for the hPOD, HUMBA and DIAMOND study teams. ‘Utility of published skin fold equations for prediction of body composition in very young New Zealand children.’ British Journal of Nutrition 2020 Apr 6:1-34 http://dx.doi.org/10.1017/S0007114520001221

 

Galante, L., Reynolds, C.M., Milan, A.M. Alexander, T., Bloomfield, F.H., Cameron-Smith, D., Pundir, S., Vickers, M.H. & the DIAMOND study group. “Preterm human milk: associations between perinatal factors and hormone concentrations throughout lactation.” Pediatric Research. 2020. https://doi.org/10.1038/s41390-020-1069-1

 

Asadi, S., Bloomfield, F., Alexander, T., McKinlay, C., Rush, E., & Harding, J. Utility of published skinfold thickness equations for prediction of body composition in very young New Zealand children. British Journal of Nutrition, 2020, 124(3), 349-360. doi:10.1017/S0007114520001221

 

GALANTE, L., REYNOLDS, C.M., MILAN, A.M., ALEXANDER, T., BLOOMFIELD, F.H., JIANG, Y., ASADI, S., MUELBERT, M., CAMERON-SMITH, D., PUNDIR, S., VICKERS, M.H. ‘Metabolic hormone profiles in breast milk from mothers of moderate-late preterm infants are associated with growth from birth to four months in a sex-specific manner.’ Frontiers in Nutrition 2021; May 28;8:641227. doi:10.3389/fnut.2021.641227

 

MUELBERT, M., GALANTE, L., ALEXANDER, T., HARDING, J.E., POOK, C., BLOOMFIELD, F.H., for the DIAMOND study group. ‘Odor active volatile compounds in preterm breastmilk.’ Pediatric Research 2021; May 7: doi: 10.1038/s41390-021-01556-w

 

MUELBERT, M., ALEXANDER, T., POOK, C. JIANG, Y., HARDING, J.E., BLOOMFIELD, F.H. ‘Cortical oxygenation changes during gastric tube feeding in moderate and late preterm babies: a NIRS study.’ Nutrients 2021 Jan 25;13(2):350. doi: 10.3390/nu13020350

 

CHONG, C.Y.L., VATANEN, T., ALEXANDER, T., BLOOMFIELD, F.H., O’SULLIVAN, J.M. ‘Factors associated with the microbiome in moderate-late preterm babies: a cohort study from the DIAMOND Randomised Controlled Trial.’ Frontiers in Cellular and Infection Microbiology. 2021; Mar 1;11:595323. doi: 10.3389/fcimb.2021.595323

 

MUELBERT, M., ALEXANDER, T., VICKERS, M.H., HARDING, J.E., GALANTE, L., BLOOMFIELD, F.H.; DIAMOND STUDY GROUP. ‘Glucocorticoids in preterm human milk.’ Frontiers in Nutrition, 2022. 9, Article number: 965654. doi: https://doi.org/10.3389/fnut.2022.965654

 

ALEXANDER, T., MEYER, M., HARDING, J.E., ALSWEILER, J.M., JIANG, Y., WALL, C., MUELBERT, M., BLOOMFIELD, F.H. ‘Nutritional management of moderate- and late-preterm infants commenced on intravenous fluids pending mother’s own milk: cohort analysis from the DIAMOND trial.’ Frontiers Pediatrics 2022 Mar 31;10:817331. doi: 10.3389/fped.2022.817331

 

Tomoko Aoyama, Tanith Alexander, Sharin Asadi, Jane E. Harding, Michael P. Meyer, Yannan Jiang, Frank H. Bloomfield, Determinants of handgrip strength at age 2 years in children born moderate and late preterm and associations with neurodevelopmental outcomes, Early Human Development, Volume 180, 2023, 105750, ISSN 0378-3782, https://doi.org/10.1016/j.earlhumdev.2023.105750

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