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Trial Name Trial ID Main Coordinating Centre
and contact		 Status Recruitment Topic Participants Details
Walking versus lying to prevent hypotension following spinal anaesthesia for caesarean section ACTRN12606000391572 allan Cyna Recruitment complete Labour and intrapartum care. Maternal medical conditions Pregnant women having spinal anaesthesia prior to caesarean section
FOREMOST trial - Fetal intrapartum pulse oximetry: a multicentre randomised controlled trial PT0360/NHMRC301050/ACTRN012606000307505 Christine East Recruitment complete Labour and intrapartum care
A pilot randomised control trial on maternal antenatal teaching for pushing in second stage of labour PUSH Study ACTRN12608000542392 hala.phipps@sswahs.nsw.gov.au Recruitment complete Labour and intrapartum care
CUT Trial - A prospective, randomised study Comparing cUrved versus straighT scissors to reduce episiotomy extension ACTRN12612000285853 Royal Brisbane & Women's Hospital angela_swift@health.qld.gov.au Recruitment complete Labour and intrapartum care
Intravenous oxytocin bolus of 2 units is superior to 5 units during elective caesarean section james_sartain@health.qld.gov.au Recruitment complete Labour and intrapartum care
FOG Trial - Outpatient Foley catheter vs inpatient Prostin gel for induction of labour ACTRN12609000420246 Royal Hospital for Women amanda.henry@sesiahs.health.nsw.gov.au Recruitment complete Labour and intrapartum care
Oral misoprostol versus intravenous oxytocin for induction of labour following artificial or spontaneous rupture of membranes jodie.dodd@adelaide.edu.au Recruitment complete Labour and intrapartum care Women > or = 41 weeks booked for delivery at Women's and Children's Hospital; singleton pregnancy; cephalic presentation
POP-OUT - Persistent Occiput Posterior: OUTcomes following manual rotation ACTRN12612001312831 Royal Prince Alfred Hospital, NSW hala.phipps@email.cs.nsw.gov.au Recruitment complete
IMPACT reviewed
 Labour and intrapartum care
Perineal outcomes and maternal comfort related to the application of perineal warm packs in the second stage of labor: a randomised controlled trial Royal Prince Alfred Women and Babies, NSW Recruitment complete Labour and intrapartum care
FLAMINGO Trial - Fetal lactate measurement to reduce caesarean sections during labour: a randomised trial ACTRN12611000172909 Royal Women`s Hospital, Vic christine.east@monash.edu Recruitment complete Labour and intrapartum care
Magnesium Sulfate for pain relief after Caesarean birth Michael Paech Recruitment complete Labour and intrapartum care
Efficacy of ultrasound guided Transversus Abdominis Plane (TAP) block following major abdominal surgery (elective caesarean section): a randomised controlled trial ACTRN12607000389404 St Vincent Hospital michael.barrington@svhm.org.au Discontinued Labour and intrapartum care
Twin birth study (TBS): a multicentred randomised controlled trial comparing planned caesarean section with planned vaginal birth for twins at 32-38 weeks gestation PT0540/ISRCTN74420086/ACTRN12606000267550 University of Toronto Dalah Mason Recruitment complete Labour and intrapartum care Twins where twin A is cephalic, gestational age 32-38 weeks, estimated fetal weight 1500-4000g, both twins alive.
Epidural Blood Patch - The Effect of Volume on efficacy- a Multi-National, Multi-Centre, Randomised Controlled Trial ACTRN12605000319673 University of Western Australia Michael Paech Recruitment complete Labour and intrapartum care
CompleTe Birth Study. Complementary medicine techniques for labour and birth: A mixed methods study. ACTRN12611001126909 University of Western Sydney, NSW 17164519@student.uws.edu.au Recruitment complete Labour and intrapartum care
Betadine Trial - Does the use of Betadine solution to wound prior to closure of skin at caesarean section affect wound healing and or infection after caesarean section? ACTRN12611000379910 Department of Obstetrics, Ipswich Hospital kassam_mahomed@health.qld.gov.au Recruitment complete Labour and intrapartum care
Pain versus comfort scores after caesarean section: a randomised trial ACTRN12610000890033 Department of Women's Anaesthesia, Women's & Children's Hospital Allan Cyna Recruitment complete Labour and intrapartum care All English speaking women who are scheduled for post-anaesthesia review following caesarean section.
MEAN ITCH Trial - Does methylnaltrexone reduce the incidence and severity of itch following spinal anaesthesia with intrathecal morphine in women undergoing caesarean delivery ACTRN12612000572864 Dept of Anaesthesia & Pain Medicine,<br>King Edward Memorial Hospital for Women michael.paech@health.wa.gov.au Recruitment complete Labour and intrapartum care
CLOSURE - Skin and subcutaneous fascia closure at caesarean section: a randomised controlled trial ACTRN12608000143325 Discipline of Obstetrics and Gynaecology, Women's and Children's Hospital rosalie.grivell@adelaide.edu.au Recruitment complete Labour and intrapartum care Women undergoing a caesarean section by transverse suprapubic incision
A comparison of fentanyl with pethidine for pain relief during childbirth ACTRN126090001027202 Flinders University/Flinders Medical Centre
Julie Fleet		 Recruitment complete Labour and intrapartum care
HATCh - The effects of antenatal hypnosis on pain relief in labour ACTRN12605000018617 / NCT00282204 Women's & Children's Hospital Allan Cyna Recruitment complete Labour and intrapartum care Previous hypnosis for childbirth; woman definitely wants an epidurtal or hypnosis; Not singleton live fetus before 34 weeks gestation; Other conditions causing pain; Active psychiatric illness.
Open versus specific questioning to assess pain during anaesthetic follow-up after caesarean birth: a randomised trial ACTRN12609000121268 Women's & Children's Hospital Allan Cyna Recruitment complete Labour and intrapartum care Women within 72 hour of their caesarean section
OSCAR - Women undergoing combined spinal epidural for elective caesarean section, ondansetron 8mg versus placebo to prevent perioperative shivering ACTRN12609000445279 Fremantle Hospital roger.browning@health.wa.gov.au Recruitment complete Labour and intrapartum care
MILO - Oral misoprostol for the induction of labour at term PT0361/ACTRN012606000156583 Women's and Children's Hospital , SA jodie.dodd@adelaide.edu.au Recruitment complete Labour and intrapartum care Singleton pregnancy, at a gestational age of 37 weeks or more, planned induction of labour for defined obstetric and medical conditions - prolonged pregnancy, pre-eclampsia, hypertensive disoreders, antepartum haemorrhage (ecluding placenta praevia), oligohydramnios, IUGR, or abnormal glucose tolerance.
Carbetocin vs oxytocin at emergency caesarean section ACTRN12612000466842 Women's Health Unit, Frankson Hospital, Vic Prof Amar Trivedi Recruitment complete Labour and intrapartum care
Balloon Trial - Caesarean section following induction of labour in nulliparous women with an unfavourable cervix: a comparison of three ripening agents - PGE2 Gel, single or double balloon catheter. ACTRN12609000186257 King Edward Memorial Hospital craig.pennell@uwa.edu.au Recruitment complete Labour and intrapartum care
COMMAND Trial - Parecoxib, celecoxib and paracetamol for pain management following caesarean delivery. ACTRN12609001041246 King Edward Memorial Hospital for Women michael.paech@health.wa.gov.au Recruitment complete Labour and intrapartum care
The use of acupressure wristbands to prevent nausea and vomiting in labour and delivery ACTRN12607000585426 King Edward Memorial Hospital for Women, Perth Michael Paech Recruitment complete Labour and intrapartum care
SWITCh - A randomised, controlled trial of a single versus a four intradermal Sterile Water Injection Technique for relief of Continuous lower back pain during labour ACTRN12609000964213 Mater Mothers' Hospital nigel.lee@mater.org.au Recruitment complete Labour and intrapartum care
The prophylactic use of a Bakri balloon for women undergoing caesarean section for placenta praevia - a randomised controlled trial Bakri ACTRN12613000348752 Mater Mothers' Research Centre/Mater Health Services Michael Beckmann Recruitment complete Labour and intrapartum care
ARRIVaL - Artificial Rupture of membranes versus Repeat Intra-Vaginal prostaglandins for induction of labour: a randomised controlled trial ACTRN12613000370707 Mater Mothers` Research Centre, Mater Health Services michael.beckmann@mater.org.au Recruitment complete Labour and intrapartum care
BAC - Birth after Caesarean. Planned vaginal birth or planned caesarean section for women at term with a single previous caesarean birth ISRCTN53974531/NHMRC349460 Maternal Perinatal Clinical Trials Unit, Adelaide Women's and Children's
Pat Ashwood		 Recruitment complete Labour and intrapartum care Women with a single prior caesarean presenting in their next pregnancy with a single live fetus in cephalic presentation who have reached 37 weeks gestation, and who don't have a contraindication to a planned VBAC.
A double-blind randomised controlled trial of oxytocin bolus plus placebo infusion versus oxytocin bolus plus oxytocin infusion at elective caesarean section ACTRN12607000631404 Monash Medical Centre joanne.mockler@med.monash.edu.au Discontinued Labour and intrapartum care Singleton pregnancy, gestation 37 - 41 weeks, elective lower segment caesarean section, regional anaesthesia (spinal, epidural, combined spinal epidural (CSE))
The ICE Pilot - Inadvertent dural puncture in labour: Intrathecal catheter versus epidural ACTRN12608000009314 allan Cyna Discontinued Labour and intrapartum care
The influence of acupuncture on the induction of labour for women with a post date pregnancy: a randomised controlled trial. PT0348 / ACTRN12606000494538 caroline.smith@uws.edu.au Recruitment complete Labour and intrapartum care Women > or = 41 weeks; singleton pregnancy; cephalic presentation
Expulsion of a retained placenta using acupuncture: a randomised controlled trial PT0347 caroline.smith@uws.edu.au Recruitment complete Labour and intrapartum care
PINK - Pregnancy iodine and neurodevelopment in kids ACTRN12610000411044 jo.zhou@adelaide.edu.au Discontinued Iodine, pregnancy, child development Mothers and children
Helping indigenous women to stop smoking during pregnancy NHMRC320851; ACTRN12609000929202 Sax Institute Sandra Eades Recruitment complete Indigenous maternal/perinatal health. Smoking in pregnancy
PIFI - Parent Infant Feeding Initiative: a study to enhance breastfeeding duration ACTRN12614000605695 Curtin University, Perth, Western Australia. Prof Jane Scott jane.scott@curtin.edu.au Recruitment complete Health promotion/education; Breastfeeding Expectant couples (mothers and fathers)
A randomized controlled trial of a specialized health coaching intervention to prevent excessive gestational weight gain and postpartum weight retention in women: the HIPP study ACTRN12611000331932 School of Psychology, Deakin University, 221 Burwood Highway, Burwood VIC 3125
Professor Helen Skouteris, Helen.skouteris@deakin.edu.au		 Recruitment complete Gestational weight gain, postpartum weight retention, health coaching Pregnant women (n=262) less than 18 weeks gestation (at recruitment), are 18 years of age or older, English speaking, with a pre-pregnancy BMI > 18.5kg/m2, and have no history of disordered eating or diabetes
txt4two - Testing the feasibility of an intervention program to promote healthy nutrition, physical activity and weight gain in pregnant women ACTRN12614000288628 Dr Jane Wilcox, School of Exercise and Nutrition Sciences, Deakin University jwillcox@deakin.edu.au Recruitment complete Gestational weight gain, mHealth, nutrition
 Eligible women were identified at their first hospital antenatal visit to a university-affiliated maternity hospital in Melbourne, Australia. Eligibility criteria included women with a singleton, live gestation between 10+0-17+6 weeks; self-reported pre-pregnancy BMI>25kg/m2; able to speak, read and write English; and owned a mobile phone.
USES Trial - Women's Opinions and Experiences of Prenatal Screening for Down Syndrome PT0355 caroline.crowther@adelaide.edu.au Recruitment complete Fetal surveillance. Fetal anomaly Women at less than 14 weeks gestation who have not had a dating scan or nuchal translucency screening
Fetal Middle Cerebral Artery Doppler (MCA) velocimetry to determine the timing of second and subsequent fetal blood transfusions in the treatment of fetal anaemia secondary to red cell alloimmunisation - a randomised controlled trial ACTRN12608000643370 The University of Adelaide, SA jodie.dodd@adelaide.edu.au Recruitment complete Fetal surveillance Pregnant women whose fetus has anaemia secondary to red cell alloimmunisation (due to any red cell antibody alone or in combination) as indicated by the need to have performed a single intra-uterine fetal blood transfusion
STRIDER (NZAus)- A randomised placebo-controlled trial of a new therapy (sildenafil) to help growth in severely growth restricted fetuses at very early gestations ACTRN12612000584831 Department of Obstetrics and Gynaecology, University of Auckland Laura Mackay (Trial Manager) laura.mackay@auckland.ac.nz; Dr Katie Groom (Chief Investigator) k.groom@auckland.ac.nz Recruitment complete
IMPACT reviewed
 Fetal growth. Preeclampsia. Pterterm birth - prevention and treatment Women with pregnancies complicated early onset fetal growth restriction. Abdominal circumference ≤3rd centile at 22-28 weeks or EFW <700g at 28-80 weeks
EPPI Trial - Enoxaparin for the Prevention of Preeclampsia and Intrauterine growth restriction ? a pilot randomised placebo-controlled trial ACTRN12609000699268 Department of Obstetrics and Gynaecology, University of Auckland. Laura Mackay (Trial Manager) laura.mackay@auckland.ac.nz; Dr Katie Groom (Chief Investigator) k.groom@auckland.ac.nz Recruitment complete
IMPACT reviewed
 Fetal growth. Preeclampsia Women with previous pregnancy complicated by early onset preeclampsia or fetal growth restriction
PLUTO - Percutaneous shunting for lower urinary tract obstruction ISRCTN53328556 The Clinical Trials Unit, University of Birmingham. Professor Mark Kilby (Chief Investigator) m.d.kilby@bham.ac.uk Recruitment complete Fetal anomaly women with pregnancy with a male fetus complicated by isolated lower urinary tract obstruction (LUTO)
WEAVE - Women's Evaluation of Abuse and Violence Care in General Practice: a cluster randomised controlled trial ACTRN12608000032358 University of Melbourne Lorna J O'Doherty Recruitment complete Family violence
MOVE Study - Improving maternal and child health care for women experiencing violence: collaborative development, implementation and effectiveness of a good practice model ACTRN12609000424202 Mother & Child Health Research, La Trobe University r.walter@latrobe.edu.au Recruitment complete Family violence
Gestational Diabetes: pregnancy outcomes in treatment with metformin compared with insulin MIG PT0521: ACTRN012605000266662 Janet Rowan Recruitment complete Diabetes. Newborn ? developmental
Effect of different diets on gestational diabetes. Can a low glycemic index (GI) diet during pregnancy reduce prevalence of large for gestation age (LGA) amongst gravidas with gestational diabetes (GDM) - a randomised controlled trial ACTRN12608000218392 Royal Prince Alfred Hospital Recruitment complete Diabetes. Maternal nutrition