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Trial Name Trial ID Main Coordinating Centre
and contact		 Status Recruitment Topic Participants Details
MobileMums: a randomized controlled trial of an SMS -based physical activity intervention. Recruitment complete Parental social and emotional wellbeing
Effectiveness of a modified mother-infant transaction program on outcomes for preterm infants from 3 to 24 months of age carol.newnham@austin.org.au Recruitment complete Parenting
HUGS - Early intervention to protect the mother-infant relationship following postnatal depression - a randomised controlled trial ACTRN12612001110875 Parent-Infant Research Institute, Austin Health, (03) 9496 4496, piri@austin.org.au
 Recruitment complete Postnatal depression, mother-infant interaction Women aged 18 years or older with an infant aged 3-9 months and a clinical diagnosis of current major or minor depressive episode
Folic Acid Clinic Trial (FACT) - Effect of folic acid supplementation in pregnancy on pre-eclampsia ISRCTN23781770; NCT01355159 Ottawa Health Research Institute, Ottawa, Canada bill.hague@adelaide.edu.au Recruitment complete Preeclampsia
HOPE Trial - Prevention of recurrent pre-eclampsia by folic acid and supplementation in women with hyperhomocysteinaemia PT0362 William Hague Recruitment complete Preeclampsia
A randomised controlled trial of dark chocolate in pregnancy for reduction in incidence of pre-eclampsia ISRCTN41164968 John James Medical Centre, Australian National University
stephen.robson@anu.edu.au		 Recruitment complete Preeclampsia
TIPPS - Thrombophilia in pregnancy prophylaxis study: a multicentre, multinational, randomised controlled trial of prophylactic low molecular weight heparin in high-risk pregnant thrombophilic women ISRCTN87441504 The University of Ottawa Hospital, Ontario, Canada, Professor Marc Rodger (Chief Investigator). Suzette Coat - Australian Coordinator Recruitment complete Preeclampsia. Fetal growth Pregnant women with thrombophilia at increased risk of venous thromboembolism or with previous placenta mediated pregnancy complication prior to 20 weeks gestation
HEPRIN - Heparin for the Prevention of complications related to placental Insufficiency ISRCTN88675588 Mt Sinai Hospital, Professor Jodie Dodd (Principal Investigator) jodie.dodd@adelaide.edu.u Recruitment complete Preeclampsia. Fetal growth Women with significant risk factors for placental insufficiency (low PAPP-A, high AFP, high inhibin, high hCG, medical and obstetric risk factors or abdnormal uterine artery Doppler)
FRUIT-Study - Low-molecular-weight heparin added to aspirin in the prevention of recurrent early-onset pre-eclampsia in women with inheritable thrombophilia ISRCTN87325378 Department of Obstetrics and Gynaecology, VU University Medical Center, Amsterdam,
Netherlands.
Prof JIP de Vries (Chief Investigator) jip.devries@vumc.nl		 Recruitment complete Preeclampsia. Fetal growth. Maternal medical conditions women with previous pregnancy with hypertensive disease and/or SGA <34 weeks and an inheritable thrombophilia
ACTS - Australasian Collaborative Trial of vitamin C and E supplementation for the prevention of pre-eclampsia ISRCTN00416244/NCT00097110/NHMRC207744 caroline.crowther@adelaide.edu.au Recruitment complete Preeclampsia. Maternal nutrition. Maternal medical conditions Nulliparous women with a singleton pregnancy, between 14-22 weeks gestation, a normal blood pressure
ACTOMgSO4 - Australasian Collaborative Trial of Magnesium Sulphate for the Prevention of Mortality and Cerebral Palsy in Infants Born Very Preterm PT0354/ACTRN012606000252516 Adelaide Women's and Children's caroline.crowther@adelaide.edu.au Recruitment complete Preterm birth ? improving outcomes (antenatal interventions) Pregnant women of gestation less than 30 weeks where delivery is planned or definately expected within 24 hours
PPROMT - Immediate delivery vs expectant care in women with preterm prelabour rupture of the membranes close to term - A randomised clinical trial PT0536/ISRCTN44485060/NHMRC358378 Dept of Obstetrics & Gynaecology, Royal North Shore Hospital ppromt@med.usyd.edu.au Recruitment complete Preterm birth ? improving outcomes (antenatal interventions) Singleton pregnancies, with confirmed ruptured membranes from 34 weeks to 36 weeks and 6 days gestation.
IRIS - A randomised clinical trial of different infusion rates of magnesium sulphate given prenatally to women for the prevention of side effects ACTRN12605000765628 Women's and Children's Hospital, SA caroline.crowther@adelaide.edu.au Recruitment complete Preterm birth ? improving outcomes (antenatal interventions) Women at less than 30 weeks gestation where birth is planned or definitely expected within 24 hours.
A*STEROID - Australasian Antenatal Study to Evaluate the Role Of Intramuscular Dexamethasone versus betamethasone prior to preterm birth to increase survival free of childhood neurosensory disability - a randomised controlled trial ACTRN12608000631303 The University of Adelaide / Women's & Children's Hospital pat.ashwood@adelaide.edu.au Recruitment complete Preterm birth ? improving outcomes (antenatal interventions). Newborn respiratory Women at risk of preterm birth at less than 34 weeks gestation, have a singleton or twin pregnancy and no contraindications to the use of antenatal corticosteroids
SMILE Study - Prevention of preterm birth by treatment of periodontal disease during pregnancy NCT00133926/NHMRC353577 ddoherty@obsgyn.uwa.edu.au Recruitment complete Preterm birth ? prevention and treatment
CiPS - Candida in Pregnancy Study - Treatment of candidiasis to prevent preterm birth - pilot study CiPS pilot ACTRN126090001052224 Royal North Shore Recruitment complete Preterm birth ? prevention and treatment
Cervical occlusion in women with cervical insufficiency: randomised, controlled trial with cerclage, with and without cervical occlusion NCT01737788 Recruitment complete Preterm birth ? prevention and treatment
NIFTY - A multi-centre randomised double blind placebo controlled trial of nifedipine maintenance tocolysis in fetal fibronectin positive women in threatened preterm labour ACTRN12613000985785 National Women's Health, Auckland Hospital. Dr Emma Parry (Principal Investigator) EmmaP@adhb.govt.nz Recruitment complete Preterm birth ? prevention and treatment Women with threatened preterm labour, a singleton pregnancy, gestational age between 24 and 34 weeks, intact membranes, positive fetal fibronectin test, completed course of corticosteroids
Improving oral hygiene to reduce the risk of preterm birth: A randomised controlled trial assessing a high intensity educational intervention ACTRN12605000767606 caroline.crowther@adelaide.edu.au Discontinued Preterm birth ? prevention and treatment Women with a singleton pregnancy
PROGRESS - Australian Collaborative trial of vaginal progesterone for prevention of neonatal respiratory distress syndrome ISRCTN20269066; NHMRC399137 Maternal Perinatal Clinical Trials Unit, Adelaide Women's and Children's Pat Ashwood Recruitment complete Preterm birth ? prevention and treatment. Preterm birth ? improving outcomes (antenatal interventions). Newborn respiratory Pregnant women with a history of prior spontaneous preterm birth at less than 34 weeks gestation
ACTORDS - Australasian Collaborative Trial of Repeat Doses of Corticosteroids for the Prevention of Neonatal Respiratory Disease ACTRN12606000318583; PT0349; ISRCTN48656428 Adelaide Women's and Children's
pat.ashwood@adelaide.edu.au		 Recruitment complete Preterm birth improving outcomes (antenatal interventions). Newborn respiratory Singleton, twin or triplet pregnancy at less than 32 weeks gestation; 7 or more days since first corticosteroid treatment, remaining at risk of preterm delivery
MPG Trial - Metformin in the Prevention of Gestational Diabetes ACTRN12610000157077 Women`s and Children`s Hospital, Children`s Youth and Women`s Health Service, North Adelaide suzette.coat@adelaide.edu.au Discontinued Prevention of recurrent Gestational diabetes Women who have had a previous pregnancy affected by GDM
An RCT of a personal financial incentive (PFI) intervention to reduce antenatal smoking in women receiving public antenatal care ACTRN12612000399897 University of Newcastle, Australia, Assoc Professor Marita Lynagh, Marita.Lynagh@newcastle.edu.au
 Recruitment complete Smoking cessation, pregnancy, financial incentives A total of 42 women were recruited to participate in the trial, representing a consent rate of 17%
A family tobacco control program to reduce respiratory illness in Indigenous infants. ACTRN12609000397213 Menzies School of Health Research/Royal Darwin Hospital Vanessa Johnston Recruitment complete Smoking in pregnancy. Indigenous maternal/perinatal health
BBB - Beating the Blues before Birth ACTRN12607000397415 Christopher Holt Recruitment complete Social and emotional wellbeing in pregnancy
Omega-3 fatty acids as a treatment for perinatal depression: randomized double-blind placebo-controlled trial Prince Alfred Hospital/University of New South Wales Recruitment complete Social and emotional wellbeing in pregnancy
The Healthy Start to Pregnancy study - an evaluation of a new early antenatal health promotion model of care for improving maternal health behaviours ACTRN12611000867998 Mater Medical Research Institute Dr Shelley Wilkinson Recruitment complete Social and emotional wellbeing in pregnancy
VITAL Trial - The effects of vitamin D supplementation in infancy on immune development ACTRN12612000787886 Childhood Allergy and Immunology Research, University of Western Australia, Dr Debbie Palmer, Ph: + 61 410 851 607, debbie.palmer@uwa.edu.au
 Recruitment complete Vitamin D, infants, immune development Infants with a family history of allergic disease