DIAMOND - DIfferent Approaches to MOderate & later preterm Nutrition: Determinants of feed tolerance, body composition and development |
ACTRN12616001199404 |
Liggins Institute, University of Auckland
t.alexander@auckland.ac.nz |
Currently recruiting
IMPACT endorsed
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Newborn nutrition Newborn body composition Neurodevelopment |
Preterm babies between 32+0 - 35+6 admitted to the neonatal unit requiring IV insertion |
View |
OPTIMIST-A - Multicentre randomised controlled trial of minimally-invasive surfactant therapy in preterm infants 25-28 weeks gestation on continuous positive airway pressure |
ACTRN12611000916943 : NCT02140580 |
Menzies Institute, UTAS (optimist.trial@utas.edu.au) |
Currently recruiting
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Minimally-invasive surfactant therapy, preterm infant, respiratory distress syndrome |
Preterm infants 25-28 weeks gestation on CPAP |
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EPAR study - Early PARacetamol (EPAR) to promote early closure of the ductus arteriosus in preterm infants |
ACTRN12616001517460 |
Department of Newborn Care, Royal Hospital for Women, Barker St, Randwick NSW 2031
Dr Timothy Schindler
tschindl@med.usyd.edu.au |
Currently recruiting
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Newborn, preterm, ductus arteriosus |
Preterm newborns |
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ProNose study - A randomised trial of a nasal barrier dressing to reduce nasal trauma in very preterm infants receiving continuous positive airway pressure (CPAP) or nasal intermittent positive pressure ventilation (NIPPV) treatment |
ACTRN12616000438459 |
The Royal Women's Hospital ; Level 7, 20 Flemington Road; Parkville, VIC 3052; Australia
Dr Brett Manley
brett.manley@thewomens.org.au |
Currently recruiting
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Newborn, respiratory, preterm, nasal trauma |
Preterm newborns |
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HATCh - The effects of antenatal hypnosis on pain relief in labour |
ACTRN12605000018617 / NCT00282204 |
Women's & Children's Hospital Allan Cyna |
Recruitment complete
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Labour and intrapartum care |
Previous hypnosis for childbirth; woman definitely wants an epidurtal or hypnosis; Not singleton live fetus before 34 weeks gestation; Other conditions causing pain; Active psychiatric illness. |
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PPROMT - Immediate delivery vs expectant care in women with preterm prelabour rupture of the membranes close to term - A randomised clinical trial |
PT0536/ISRCTN44485060/NHMRC358378 |
Dept of Obstetrics & Gynaecology, Royal North Shore Hospital ppromt@med.usyd.edu.au |
Recruitment complete
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Preterm birth ? improving outcomes (antenatal interventions) |
Singleton pregnancies, with confirmed ruptured membranes from 34 weeks to 36 weeks and 6 days gestation. |
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MILO - Oral misoprostol for the induction of labour at term |
PT0361/ACTRN012606000156583 |
Women's and Children's Hospital , SA jodie.dodd@adelaide.edu.au |
Recruitment complete
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Labour and intrapartum care |
Singleton pregnancy, at a gestational age of 37 weeks or more, planned induction of labour for defined obstetric and medical conditions - prolonged pregnancy, pre-eclampsia, hypertensive disoreders, antepartum haemorrhage (ecluding placenta praevia), oligohydramnios, IUGR, or abnormal glucose tolerance. |
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A double-blind randomised controlled trial of oxytocin bolus plus placebo infusion versus oxytocin bolus plus oxytocin infusion at elective caesarean section |
ACTRN12607000631404 |
Monash Medical Centre joanne.mockler@med.monash.edu.au |
Discontinued
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Labour and intrapartum care |
Singleton pregnancy, gestation 37 - 41 weeks, elective lower segment caesarean section, regional anaesthesia (spinal, epidural, combined spinal epidural (CSE)) |
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ACTORDS - Australasian Collaborative Trial of Repeat Doses of Corticosteroids for the Prevention of Neonatal Respiratory Disease |
ACTRN12606000318583; PT0349; ISRCTN48656428 |
Adelaide Women's and Children's
pat.ashwood@adelaide.edu.au |
Recruitment complete
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Preterm birth improving outcomes (antenatal interventions). Newborn respiratory |
Singleton, twin or triplet pregnancy at less than 32 weeks gestation; 7 or more days since first corticosteroid treatment, remaining at risk of preterm delivery |
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Foley Catheter Latex versus Silicone for Cervical Ripening Prior to Term Induction of Labour: a randomized controlled trial |
ACTRN12615000795594 |
Westmead Hospital; Dr Terry McGee, Terry.McGee@health.nsw.gov.au |
Currently recruiting
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Latex; Silicon; Foley catheter |
This is a prospective randomized clinical trial that is carried out in the Day Assessment Unit and the Birth Unit (the usual sites of Foley catheter insertion) at Westmead Hospital . All women 16 years and over booked for cervical ripening with a Foley catheter before term induction of labour are asked to participate in the study.
Apart from the randomization of catheter material (latex v silicone) all other care will be identical to women not participating in the study.
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Twin birth study (TBS): a multicentred randomised controlled trial comparing planned caesarean section with planned vaginal birth for twins at 32-38 weeks gestation |
PT0540/ISRCTN74420086/ACTRN12606000267550 |
University of Toronto Dalah Mason |
Recruitment complete
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Labour and intrapartum care |
Twins where twin A is cephalic, gestational age 32-38 weeks, estimated fetal weight 1500-4000g, both twins alive. |
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TASTE - Effect of smell and taste to improve nutrition in very preterm babies |
ACTRN12617000583347 |
Neonatal Critical Care Unit, Mater Mothers' Hospital, QLD 4101
Dr Friederike Beker
friederike.beker@mater.org.au |
Currently recruiting
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Newborn, nutrition, preterm, tube feeding |
Very preterm newborns |
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The impact of pH on fertilisation in human oocytes |
ACTRN12617000230358 |
Westmead Fertility Centre; Westmead Hospital, Westmead NSW 2145
Dr Cecilia Sjoblom
cecilia.sjoblom@sydney.edu.au |
Not yet recruiting
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Reproductive medicine, IVF fertilisation methods |
Women |
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NIPA Trial (Nifedipine for improving Implantation and Pregnancy rates in ART) Does nifedipine improve implantation and pregnancy rates in women undergoing in-vitro fertilisation (IVF)/intracytoplasmic sperm injection (ICSI) cycles? |
ACTRN12617000213347 |
Melbourne IVF, East Melbourne, VIC, 3002
Dr Alex Polyakov
alex.polyakov@mivf.com.au |
Currently recruiting
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Reproductive medicine, IVF implantation, nifedipine |
Women |
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Oral misoprostol versus intravenous oxytocin for induction of labour following artificial or spontaneous rupture of membranes |
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jodie.dodd@adelaide.edu.au |
Recruitment complete
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Labour and intrapartum care |
Women > or = 41 weeks booked for delivery at Women's and Children's Hospital; singleton pregnancy; cephalic presentation |
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The influence of acupuncture on the induction of labour for women with a post date pregnancy: a randomised controlled trial. |
PT0348 / ACTRN12606000494538 |
caroline.smith@uws.edu.au |
Recruitment complete
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Labour and intrapartum care |
Women > or = 41 weeks; singleton pregnancy; cephalic presentation |
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A RCT of pregnant women being monitored during labour with ST analysis monitoring and cardiotocography compared to being monitored with cardiotocography alone in order to reduce caesarean section whilst still having comparable outcomes for the baby. |
ACTRN12615001308583 |
Women's & Children's Hospital, Adelaide chrisswilkinson@mac.com |
Currently recruiting
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Labour and intrapartum care |
Women >= 18 years, gestation >36 completed weeks, expected to labour and deliver vaginally, singleton fetus, cephalic presentation, suitable for STan monitoring. |
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HUGS - Early intervention to protect the mother-infant relationship following postnatal depression - a randomised controlled trial |
ACTRN12612001110875 |
Parent-Infant Research Institute, Austin Health, (03) 9496 4496, piri@austin.org.au
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Recruitment complete
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Postnatal depression, mother-infant interaction |
Women aged 18 years or older with an infant aged 3-9 months and a clinical diagnosis of current major or minor depressive episode |
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GEMS - Gestational diabetes trial of detection thresholds: Impact on health and costs |
ACTRN12615000290594 |
Liggins Institute, GEMS@auckland.ac.nz |
Currently recruiting
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Gestational diabetes, diagnostic thresholds, birthweight |
Women at >24 weeks’ gestation having a oral glucose tolerance test for gestational diabetes |
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USES Trial - Women's Opinions and Experiences of Prenatal Screening for Down Syndrome |
PT0355 |
caroline.crowther@adelaide.edu.au |
Recruitment complete
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Fetal surveillance. Fetal anomaly |
Women at less than 14 weeks gestation who have not had a dating scan or nuchal translucency screening |
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ORIP - Omega-3 fats to reduce the incidence of prematurity |
ACTRN12613001142729 |
Women`s and Children`s Health Research Institute, SA (WCH) jo.zhou@adelaide.edu.au |
Currently recruiting
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Preterm birth ? prevention and treatment. Maternal nutrition |
Women at less than 20 weeks' gestation |
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IRIS - A randomised clinical trial of different infusion rates of magnesium sulphate given prenatally to women for the prevention of side effects |
ACTRN12605000765628 |
Women's and Children's Hospital, SA caroline.crowther@adelaide.edu.au |
Recruitment complete
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Preterm birth ? improving outcomes (antenatal interventions) |
Women at less than 30 weeks gestation where birth is planned or definitely expected within 24 hours. |
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A*STEROID - Australasian Antenatal Study to Evaluate the Role Of Intramuscular Dexamethasone versus betamethasone prior to preterm birth to increase survival free of childhood neurosensory disability - a randomised controlled trial |
ACTRN12608000631303 |
The University of Adelaide / Women's & Children's Hospital pat.ashwood@adelaide.edu.au |
Recruitment complete
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Preterm birth ? improving outcomes (antenatal interventions). Newborn respiratory |
Women at risk of preterm birth at less than 34 weeks gestation, have a singleton or twin pregnancy and no contraindications to the use of antenatal corticosteroids |
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MAGENTA - Does antenatal magnesium sulphate given to women at risk of preterm birth between 30 and 34 weeks' gestation reduce the risk of death or cerebral palsy in their children? - a randomised controlled trial. |
ACTRN126110000491965 |
University of Adelaide, Clinical Trial Manager Pat Ashwood +61 8 8161 7767
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Currently recruiting
IMPACT reviewed
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Neuroprotection, Antenatal magnesium sulphate, Cerebral palsy
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Women at risk of preterm birth between 30 and 34 weeks’ gestation where birth is planned or definitely expected within 24 hours, have a singleton or twin pregnancy, no contraindications to the use of antenatal magnesium sulphate |
View |
IDEAL - Dietary and Lifestyle advice for women with borderline gestational glucose intolerance |
ACTRN12607000174482 |
Australian Research Centre for Health of Women and Babies (ARCH), The University of Adelaide pat.ashwood@adelaide.edu.au |
Recruitment complete
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Diabetes. Maternal nutrition |
Women between 24 weeks 0 days and 34 weeks 6 days gestation with a singleton pregnancy, with a positive OGCT (venous plasma glucose >=7.8 mmol/L) and a normal 75 gram OGTT (fasting venous plasma glucose <5.5 mmol/L and a 2 hour glucose <7.8 mmol/L), |
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CLOSURE - Skin and subcutaneous fascia closure at caesarean section: a randomised controlled trial |
ACTRN12608000143325 |
Discipline of Obstetrics and Gynaecology, Women's and Children's Hospital rosalie.grivell@adelaide.edu.au |
Recruitment complete
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Labour and intrapartum care |
Women undergoing a caesarean section by transverse suprapubic incision |
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STREAM - Effect of ovarian stimulation on oocyte quality and embryonic aneuploidy: a prospective, randomised controlled trial |
ACTRN12616001539426 |
School of Women’s &, Children’s Health, Royal Hospital for Women, NSW 2031
Prof William Ledger
w.ledger@unsw.edu.au |
Currently recruiting
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Reproductive medicine, IVF, ovarian stimulation |
Women undergoing fertility treatment |
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FAST - Comparison of the probability of live birth after elective freezing of all embryos versus standard fresh embryo transfer in patients undergoing in-vitro fertilisation (IVF) |
ACTRN12616000643471 |
IVF Australia Southern Sydney, St George Private Hospital, NSW
Dr Christos Venetis
c.venetis@unsw.edu.au |
Not yet recruiting
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Reproductive medicine, IVF fertilisation methods, embryo transfer |
Women undergoing fertility treatment |
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MPG Trial - Metformin in the Prevention of Gestational Diabetes |
ACTRN12610000157077 |
Women`s and Children`s Hospital, Children`s Youth and Women`s Health Service, North Adelaide suzette.coat@adelaide.edu.au |
Discontinued
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Prevention of recurrent Gestational diabetes |
Women who have had a previous pregnancy affected by GDM |
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Help-seeking for postnatal depression as a major public health problem: A cluster randomised controlled trial of motivational interviewing |
ACTRN12611000635965 |
Parent-Infant Research Institute, Austin Health, (03) 9496 4496, piri@austin.org.au
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Recruitment complete
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Motivational interviewing, postnatal depression |
Women with a 4-week old baby |
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BAC - Birth after Caesarean. Planned vaginal birth or planned caesarean section for women at term with a single previous caesarean birth |
ISRCTN53974531/NHMRC349460 |
Maternal Perinatal Clinical Trials Unit, Adelaide Women's and Children's
Pat Ashwood |
Recruitment complete
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Labour and intrapartum care |
Women with a single prior caesarean presenting in their next pregnancy with a single live fetus in cephalic presentation who have reached 37 weeks gestation, and who don't have a contraindication to a planned VBAC. |
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Improving oral hygiene to reduce the risk of preterm birth: A randomised controlled trial assessing a high intensity educational intervention |
ACTRN12605000767606 |
caroline.crowther@adelaide.edu.au |
Discontinued
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Preterm birth ? prevention and treatment |
Women with a singleton pregnancy |
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GRoW - Metformin and dietary advice to improve insulin sensitivity and promote gestational restriction of weight in pregnant women who are obese - a randomised trial |
ACTRN12612001277831 |
Discipline of Obstetrics & Gynaecology, The University of Adelaide andrea.deussen@adelaide.edu.au |
Currently recruiting
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Obesity. Maternal nutrition |
Women with a singleton, live gestation between 10 +0 and 20 +0 weeks gestation with a BMI above or equal to 30 kg/m2 at their first antenatal visit. |
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OPTIMISE - Optimising gestational weight gain and improving maternal and infant health outcomes through antenatal dietary, lifestyle and exercise advice, the randomised trial |
ACTRN12614000583640 |
The University of Adelaide jodie.dodd@adelaide.edu.au |
Currently recruiting
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Women with a singleton, live gestation between 10+0-20+0 weeks who are of normal BMI (defined as a BMI 18.5-24.9kg/m2), at the time of the first antenatal visit. |
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ACTOTTAB - Twins: Timing of birth at Term |
PT0426/ISRCTN15761056 |
WCH, Adelaide Jodie Dodd |
Recruitment complete
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Labour and intrapartum care. Models of care |
Women with a twin pregnancy at 37 weeks gestation |
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DIAMIND - Diabetes SMS text reminders versus standard care for women who have had gestational diabetes mellitus to increase the rate of oral glucose testing in the postpartum period |
ACTRN12612000621819 |
Australian Research Centre for Health of Women & Babies, The University of Adelaide emer.heatley@adelaide.edu.au |
Recruitment complete
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Diabetes. Maternal medical conditions |
Women with GDM in current pregnancy, singleton or twin pregnancy, with access to a mobile phone, postnatal blood glucose that level returned to normal before discharge |
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TARGET - Optimal glycaemic targets for gestational diabetes: the randomised trial |
ACTRN12615000282583 |
Liggins Institute, target@auckland.ac.nz |
Currently recruiting
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Gestational diabetes, glycemic control, birthweight |
Women with gestational diabetes |
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The PROTECT Me trial |
RES-17-0000-583A |
Monash Medical Centre Clayton
Dr Kirsten Palmer
kirsten.palmer@monash.edu |
Currently recruiting
IMPACT endorsed
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Early onset Intrauterine Fetal Growth Restriction |
Women with pregnancies complicated by severe fetal growth restriction between 23+0 and 31+6 weeks gestation |
View |
STRIDER (NZAus)- A randomised placebo-controlled trial of a new therapy (sildenafil) to help growth in severely growth restricted fetuses at very early gestations |
ACTRN12612000584831 |
Department of Obstetrics and Gynaecology, University of Auckland Laura Mackay (Trial Manager) laura.mackay@auckland.ac.nz; Dr Katie Groom (Chief Investigator) k.groom@auckland.ac.nz |
Recruitment complete
IMPACT reviewed
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Fetal growth. Preeclampsia. Pterterm birth - prevention and treatment |
Women with pregnancies complicated early onset fetal growth restriction. Abdominal circumference ≤3rd centile at 22-28 weeks or EFW <700g at 28-80 weeks |
View |
PLUTO - Percutaneous shunting for lower urinary tract obstruction |
ISRCTN53328556 |
The Clinical Trials Unit, University of Birmingham. Professor Mark Kilby (Chief Investigator) m.d.kilby@bham.ac.uk |
Recruitment complete
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Fetal anomaly |
women with pregnancy with a male fetus complicated by isolated lower urinary tract obstruction (LUTO) |
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EPPI Trial - Enoxaparin for the Prevention of Preeclampsia and Intrauterine growth restriction ? a pilot randomised placebo-controlled trial |
ACTRN12609000699268 |
Department of Obstetrics and Gynaecology, University of Auckland. Laura Mackay (Trial Manager) laura.mackay@auckland.ac.nz; Dr Katie Groom (Chief Investigator) k.groom@auckland.ac.nz |
Recruitment complete
IMPACT reviewed
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Fetal growth. Preeclampsia |
Women with previous pregnancy complicated by early onset preeclampsia or fetal growth restriction |
View |
FRUIT-Study - Low-molecular-weight heparin added to aspirin in the prevention of recurrent early-onset pre-eclampsia in women with inheritable thrombophilia |
ISRCTN87325378 |
Department of Obstetrics and Gynaecology, VU University Medical Center, Amsterdam,
Netherlands.
Prof JIP de Vries (Chief Investigator) jip.devries@vumc.nl |
Recruitment complete
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Preeclampsia. Fetal growth. Maternal medical conditions |
women with previous pregnancy with hypertensive disease and/or SGA <34 weeks and an inheritable thrombophilia
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HEPRIN - Heparin for the Prevention of complications related to placental Insufficiency |
ISRCTN88675588 |
Mt Sinai Hospital, Professor Jodie Dodd (Principal Investigator) jodie.dodd@adelaide.edu.u |
Recruitment complete
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Preeclampsia. Fetal growth |
Women with significant risk factors for placental insufficiency (low PAPP-A, high AFP, high inhibin, high hCG, medical and obstetric risk factors or abdnormal uterine artery Doppler) |
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NIFTY - A multi-centre randomised double blind placebo controlled trial of nifedipine maintenance tocolysis in fetal fibronectin positive women in threatened preterm labour |
ACTRN12613000985785 |
National Women's Health, Auckland Hospital. Dr Emma Parry (Principal Investigator) EmmaP@adhb.govt.nz |
Recruitment complete
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Preterm birth ? prevention and treatment |
Women with threatened preterm labour, a singleton pregnancy, gestational age between 24 and 34 weeks, intact membranes, positive fetal fibronectin test, completed course of corticosteroids |
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Open versus specific questioning to assess pain during anaesthetic follow-up after caesarean birth: a randomised trial |
ACTRN12609000121268 |
Women's & Children's Hospital Allan Cyna |
Recruitment complete
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Labour and intrapartum care |
Women within 72 hour of their caesarean section |
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