| Trial Name | Trial ID | Main Coordinating Centre and contact |
Status Recruitment | Topic | Participants |
|---|---|---|---|---|---|
| VITAL Trial - The effects of vitamin D supplementation in infancy on immune development | ACTRN12612000787886 | Childhood Allergy and Immunology Research, University of Western Australia, Dr Debbie Palmer, Ph: + 61 410 851 607, debbie.palmer@uwa.edu.au |
Recruitment complete | Vitamin D, infants, immune development | Infants with a family history of allergic disease |
| BBB - Beating the Blues before Birth | ACTRN12607000397415 | Christopher Holt | Recruitment complete | Social and emotional wellbeing in pregnancy | |
| Omega-3 fatty acids as a treatment for perinatal depression: randomized double-blind placebo-controlled trial | Prince Alfred Hospital/University of New South Wales | Recruitment complete | Social and emotional wellbeing in pregnancy | ||
| The Healthy Start to Pregnancy study - an evaluation of a new early antenatal health promotion model of care for improving maternal health behaviours | ACTRN12611000867998 | Mater Medical Research Institute Dr Shelley Wilkinson | Recruitment complete | Social and emotional wellbeing in pregnancy | |
| A family tobacco control program to reduce respiratory illness in Indigenous infants. | ACTRN12609000397213 | Menzies School of Health Research/Royal Darwin Hospital Vanessa Johnston | Recruitment complete | Smoking in pregnancy. Indigenous maternal/perinatal health | |
| An RCT of a personal financial incentive (PFI) intervention to reduce antenatal smoking in women receiving public antenatal care | ACTRN12612000399897 | University of Newcastle, Australia, Assoc Professor Marita Lynagh, Marita.Lynagh@newcastle.edu.au |
Recruitment complete | Smoking cessation, pregnancy, financial incentives | A total of 42 women were recruited to participate in the trial, representing a consent rate of 17% |
| MPG Trial - Metformin in the Prevention of Gestational Diabetes | ACTRN12610000157077 | Women`s and Children`s Hospital, Children`s Youth and Women`s Health Service, North Adelaide suzette.coat@adelaide.edu.au | Discontinued | Prevention of recurrent Gestational diabetes | Women who have had a previous pregnancy affected by GDM |
| ACTORDS - Australasian Collaborative Trial of Repeat Doses of Corticosteroids for the Prevention of Neonatal Respiratory Disease | ACTRN12606000318583; PT0349; ISRCTN48656428 | Adelaide Women's and Children's pat.ashwood@adelaide.edu.au |
Recruitment complete | Preterm birth improving outcomes (antenatal interventions). Newborn respiratory | Singleton, twin or triplet pregnancy at less than 32 weeks gestation; 7 or more days since first corticosteroid treatment, remaining at risk of preterm delivery |
| PROGRESS - Australian Collaborative trial of vaginal progesterone for prevention of neonatal respiratory distress syndrome | ISRCTN20269066; NHMRC399137 | Maternal Perinatal Clinical Trials Unit, Adelaide Women's and Children's Pat Ashwood | Recruitment complete | Preterm birth ? prevention and treatment. Preterm birth ? improving outcomes (antenatal interventions). Newborn respiratory | Pregnant women with a history of prior spontaneous preterm birth at less than 34 weeks gestation |
| SMILE Study - Prevention of preterm birth by treatment of periodontal disease during pregnancy | NCT00133926/NHMRC353577 | ddoherty@obsgyn.uwa.edu.au | Recruitment complete | Preterm birth ? prevention and treatment | |
| CiPS - Candida in Pregnancy Study - Treatment of candidiasis to prevent preterm birth - pilot study CiPS pilot | ACTRN126090001052224 | Royal North Shore | Recruitment complete | Preterm birth ? prevention and treatment | |
| Cervical occlusion in women with cervical insufficiency: randomised, controlled trial with cerclage, with and without cervical occlusion | NCT01737788 | Recruitment complete | Preterm birth ? prevention and treatment | ||
| NIFTY - A multi-centre randomised double blind placebo controlled trial of nifedipine maintenance tocolysis in fetal fibronectin positive women in threatened preterm labour | ACTRN12613000985785 | National Women's Health, Auckland Hospital. Dr Emma Parry (Principal Investigator) EmmaP@adhb.govt.nz | Recruitment complete | Preterm birth ? prevention and treatment | Women with threatened preterm labour, a singleton pregnancy, gestational age between 24 and 34 weeks, intact membranes, positive fetal fibronectin test, completed course of corticosteroids |
| Improving oral hygiene to reduce the risk of preterm birth: A randomised controlled trial assessing a high intensity educational intervention | ACTRN12605000767606 | caroline.crowther@adelaide.edu.au | Discontinued | Preterm birth ? prevention and treatment | Women with a singleton pregnancy |
| A*STEROID - Australasian Antenatal Study to Evaluate the Role Of Intramuscular Dexamethasone versus betamethasone prior to preterm birth to increase survival free of childhood neurosensory disability - a randomised controlled trial | ACTRN12608000631303 | The University of Adelaide / Women's & Children's Hospital pat.ashwood@adelaide.edu.au | Recruitment complete | Preterm birth ? improving outcomes (antenatal interventions). Newborn respiratory | Women at risk of preterm birth at less than 34 weeks gestation, have a singleton or twin pregnancy and no contraindications to the use of antenatal corticosteroids |
| ACTOMgSO4 - Australasian Collaborative Trial of Magnesium Sulphate for the Prevention of Mortality and Cerebral Palsy in Infants Born Very Preterm | PT0354/ACTRN012606000252516 | Adelaide Women's and Children's caroline.crowther@adelaide.edu.au | Recruitment complete | Preterm birth ? improving outcomes (antenatal interventions) | Pregnant women of gestation less than 30 weeks where delivery is planned or definately expected within 24 hours |
| PPROMT - Immediate delivery vs expectant care in women with preterm prelabour rupture of the membranes close to term - A randomised clinical trial | PT0536/ISRCTN44485060/NHMRC358378 | Dept of Obstetrics & Gynaecology, Royal North Shore Hospital ppromt@med.usyd.edu.au | Recruitment complete | Preterm birth ? improving outcomes (antenatal interventions) | Singleton pregnancies, with confirmed ruptured membranes from 34 weeks to 36 weeks and 6 days gestation. |
| IRIS - A randomised clinical trial of different infusion rates of magnesium sulphate given prenatally to women for the prevention of side effects | ACTRN12605000765628 | Women's and Children's Hospital, SA caroline.crowther@adelaide.edu.au | Recruitment complete | Preterm birth ? improving outcomes (antenatal interventions) | Women at less than 30 weeks gestation where birth is planned or definitely expected within 24 hours. |
| ACTS - Australasian Collaborative Trial of vitamin C and E supplementation for the prevention of pre-eclampsia | ISRCTN00416244/NCT00097110/NHMRC207744 | caroline.crowther@adelaide.edu.au | Recruitment complete | Preeclampsia. Maternal nutrition. Maternal medical conditions | Nulliparous women with a singleton pregnancy, between 14-22 weeks gestation, a normal blood pressure |
| FRUIT-Study - Low-molecular-weight heparin added to aspirin in the prevention of recurrent early-onset pre-eclampsia in women with inheritable thrombophilia | ISRCTN87325378 | Department of Obstetrics and Gynaecology, VU University Medical Center, Amsterdam, Netherlands. Prof JIP de Vries (Chief Investigator) jip.devries@vumc.nl |
Recruitment complete | Preeclampsia. Fetal growth. Maternal medical conditions | women with previous pregnancy with hypertensive disease and/or SGA <34 weeks and an inheritable thrombophilia |
| TIPPS - Thrombophilia in pregnancy prophylaxis study: a multicentre, multinational, randomised controlled trial of prophylactic low molecular weight heparin in high-risk pregnant thrombophilic women | ISRCTN87441504 | The University of Ottawa Hospital, Ontario, Canada, Professor Marc Rodger (Chief Investigator). Suzette Coat - Australian Coordinator | Recruitment complete | Preeclampsia. Fetal growth | Pregnant women with thrombophilia at increased risk of venous thromboembolism or with previous placenta mediated pregnancy complication prior to 20 weeks gestation |
| HEPRIN - Heparin for the Prevention of complications related to placental Insufficiency | ISRCTN88675588 | Mt Sinai Hospital, Professor Jodie Dodd (Principal Investigator) jodie.dodd@adelaide.edu.u | Recruitment complete | Preeclampsia. Fetal growth | Women with significant risk factors for placental insufficiency (low PAPP-A, high AFP, high inhibin, high hCG, medical and obstetric risk factors or abdnormal uterine artery Doppler) |
| Folic Acid Clinic Trial (FACT) - Effect of folic acid supplementation in pregnancy on pre-eclampsia | ISRCTN23781770; NCT01355159 | Ottawa Health Research Institute, Ottawa, Canada bill.hague@adelaide.edu.au | Recruitment complete | Preeclampsia | |
| HOPE Trial - Prevention of recurrent pre-eclampsia by folic acid and supplementation in women with hyperhomocysteinaemia | PT0362 | William Hague | Recruitment complete | Preeclampsia | |
| A randomised controlled trial of dark chocolate in pregnancy for reduction in incidence of pre-eclampsia | ISRCTN41164968 | John James Medical Centre, Australian National University stephen.robson@anu.edu.au |
Recruitment complete | Preeclampsia | |
| HUGS - Early intervention to protect the mother-infant relationship following postnatal depression - a randomised controlled trial | ACTRN12612001110875 | Parent-Infant Research Institute, Austin Health, (03) 9496 4496, piri@austin.org.au |
Recruitment complete | Postnatal depression, mother-infant interaction | Women aged 18 years or older with an infant aged 3-9 months and a clinical diagnosis of current major or minor depressive episode |
| Effectiveness of a modified mother-infant transaction program on outcomes for preterm infants from 3 to 24 months of age | carol.newnham@austin.org.au | Recruitment complete | Parenting | ||
| Brief antenatal cognitive behaviour therapy group intervention for the prevention of postnatal depression and anxiety: a randomised controlled trial | RHW, Sydney | Recruitment complete | Parental social and emotional wellbeing | ||
| PRIME - The effect of midwife-led counselling on mental health outcomes for women experiencing a traumatic childbirth: a randomised controlled trial | ACTRN12610000098033 | j.gamble@griffith.edu.au | Recruitment complete | Parental social and emotional wellbeing | |
| Perinatal treatment of depression | ACTRN12609000831280 | Royal Brisbane Hospital Sally Matherson | Suspended | Parental social and emotional wellbeing | |
| Effect of the 'Mother and Baby' program on new mothers' psychological and physical well-being | NCT00361478 | The Angliss Hospital, Vic | Recruitment complete | Parental social and emotional wellbeing | |
| Three model care pathways for postnatal depression | NCT01002027 | Austin Health, Vic Jeanette Milgrom | Recruitment complete | Parental social and emotional wellbeing | |
| Baby Business: the first few months of life. The impact of a brief universal parenting program to prevent early infant sleep and cry problems and associated parental depression: a randomised controlled trial | ISRCTN63834603 | Centre for Community Child Health, Royal Children's Hospital Dr Harriet Hiscock | Recruitment complete | Parental social and emotional wellbeing | |
| The virtual infant parenting program: a randomised controlled trial | ISRCTN24952438 | Centre for Devel Health, Curtin Heath Innov Res Inst, Curtin University of Technology Prof Sven Silburn | Recruitment complete | Parental social and emotional wellbeing | |
| MobileMums: a randomized controlled trial of an SMS -based physical activity intervention. | Recruitment complete | Parental social and emotional wellbeing | |||
| Fighting obesity from conception- a randomised trial | ACTRN12605000709640; PT0543 | Julie Quinlivan | Recruitment complete | Obesity. Maternal nutrition | |
| LIMIT - Limiting weight gain in overweight and obese women during pregnancy to improve health outcomes: a randomised trial | ACTRN12607000161426 | Women's and Children's Hospital Andrea Deussen | Recruitment complete | Obesity. Maternal nutrition | Pregnant women with a singleton, live gestation between 10+0 - 20 weeks who are obese or overweight (defined as a body mass index greater that 25kg/m2) |
| HeLP-her - Healthier lifestyles: Preventing excess weight gain and gestational diabetes in overweight and obese pregnancies: a research and education project | ACTRN12608000233325 | Jean Hailes Research Group for Womens Health and Monash Institute of Health Services Research (Southern Health)MIMR | Recruitment complete | Obesity. Diabetes | |
| Weighing pregnant women to achieve ideal weight gains in pregnancy | ACTRN12607000272493 | Mercy Hospital | Recruitment complete | Obesity | |
| Supervised home-based exercise may attenuate the decline of glucose tolerance in obese pregnant women | Assoc/Prof Kym Guelfi | Recruitment complete | Obesity | ||
| MONT (mask or nasal tube) Trial: A randomised controlled trial of mask versus nasal tube for the stabilisation of preterm infants (born between 24 and 29 complete weeks gestation) in the delivery room | ACTRN12610000230055; NTR2061 | Newborn Services and Neonatal Research, Royal Women's Hospital Omar Kamlin | Recruitment complete | Newborn resuscitation | |
| A comparison of Propofol and Suxamethonium as induction agents for neonatal endotracheal intubation | PT0545 | Julee Oei | Recruitment complete | Newborn respiratory. Newborn resuscitation | |
| The effects of nasal continuous positive airway pressure on cardiac function in (i) premature infants with established lung disease and (ii) premature infants with minimal lung disease. | ACTRN12611001057976 | Royal Women's Hospital, Vic sheryle.rogerson@the womens.org.au | Recruitment complete | Newborn respiratory. Newborn cardiovascular | |
| OPTIMIST-B - Multicentre randomised controlled trial of minimally-invastive surfactant therapy in preterm infants 29-32 weeks gestation on continuous positive airway pressure | ACTRN12611000917932 | Royal Hobart Hospital, Tas peter.dargaville@dhhs.tas.gov.au | Discontinued | Newborn respiratory | |
| AC/VG Flow Study - Ventilator circuit flow selection during neonatal assist control volume guarantee ventilation: a randomised crossover trial. | ACTRN12610000885099 | Kevin Wheeler | Recruitment complete | Newborn respiratory | |
| AC/VG Pmax Study - Pressure limit selection during neonatal assist control volume guarantee ventilation: A randomised crossover trial. | ACTRN12610000886088 | kevin.wheeler@thewomens.org.au | Recruitment complete | Newborn respiratory | |
| The effect of sildenafil in preterm infants with evolving chronic lung disease | NCT00431418 | kkonig@mercy.com.au | Recruitment complete | Newborn respiratory | |
| HIPERSPACE - Comparing the failure rate of high-flow nasal cannulae (HFNC) versus nasal continuous positive airway pressure (CPAP) as post-extubation respiratory support in premature infants with gestational age of 24 to 32 weeks. | ACTRN12610000166077 | Royal Women's Hospital, Vic Dr Brett Manley | Recruitment complete | Newborn respiratory | |
| AC/VG BUR Study - Backup rate selection during neonatal assist control volume guarantee ventilation: a randomised crossover trial. | ACTRN12610000884000 | Royal Women's Hospital kevin.wheeler@thewomens.org.au |
Recruitment complete | Newborn respiratory | |
| HiFloW Trial - A randomised controlled trial to evaluate the effectiveness of heated, humidified high flow nasal cannula (HHHFNC) in the withdrawal of nasal continuous positive airway pressure (nCPAP) in preterm infants | ACTRN12610001003066 | RPA Hospital, Sydney david.osborn@email.cs.nsw.gov.au | Recruitment complete | Newborn respiratory |