| Trial Name | Trial ID | Main Coordinating Centre and contact |
Status Recruitment | Topic | Participants |
|---|---|---|---|---|---|
| VITAL Trial - The effects of vitamin D supplementation in infancy on immune development | ACTRN12612000787886 | Childhood Allergy and Immunology Research, University of Western Australia, Dr Debbie Palmer, Ph: + 61 410 851 607, debbie.palmer@uwa.edu.au |
Recruitment complete | Vitamin D, infants, immune development | Infants with a family history of allergic disease |
| WASH*T - Effect of transfusion of washed red blood cells on neonatal outcome: a randomised controlled trial | ACTRN12613000237785 | Women's & Children's Hospital, SA michael.stark@adelaide.edu.au | Currently recruiting | Transfusion, Immunology and Neonatal Outcomes | Infants born with a gestational age up to 28 weeks 6 days clinically requiring a packed red blood cell transfusion transfusion. |
| MBM - My Baby’s Movements: a stepped wedge cluster randomised controlled trial to raise maternal awareness of fetal movements during pregnancy | ACTRN12614000291684 | Mater Research Institute - The University of Queensland u.chandrasiri@mater.uq.edu.au |
Not yet recruiting
IMPACT endorsed
|
Stillbirth prevention. Fetal surveillance. Parental social and emotional wellbeing. | Pregnant women without any congenital abnormalities |
| BBB - Beating the Blues before Birth | ACTRN12607000397415 | Christopher Holt | Recruitment complete | Social and emotional wellbeing in pregnancy | |
| Omega-3 fatty acids as a treatment for perinatal depression: randomized double-blind placebo-controlled trial | Prince Alfred Hospital/University of New South Wales | Recruitment complete | Social and emotional wellbeing in pregnancy | ||
| The Healthy Start to Pregnancy study - an evaluation of a new early antenatal health promotion model of care for improving maternal health behaviours | ACTRN12611000867998 | Mater Medical Research Institute Dr Shelley Wilkinson | Recruitment complete | Social and emotional wellbeing in pregnancy | |
| A family tobacco control program to reduce respiratory illness in Indigenous infants. | ACTRN12609000397213 | Menzies School of Health Research/Royal Darwin Hospital Vanessa Johnston | Recruitment complete | Smoking in pregnancy. Indigenous maternal/perinatal health | |
| An RCT of a personal financial incentive (PFI) intervention to reduce antenatal smoking in women receiving public antenatal care | ACTRN12612000399897 | University of Newcastle, Australia, Assoc Professor Marita Lynagh, Marita.Lynagh@newcastle.edu.au |
Recruitment complete | Smoking cessation, pregnancy, financial incentives | A total of 42 women were recruited to participate in the trial, representing a consent rate of 17% |
| FIB-UPFRONT PPH - The effect of Upfront Administration of Fibrinogen concentrate on total blood volume loss in Obstetric Haemorrhage ? A Pilot study | ACTRN12614000691640 | National Women's Health, Auckland City Hospital jayv@adhb.govt.nz | Currently recruiting | Severe postpartum haemorrahge Fibrinogen concentrate ROTEM |
Postpartum women with haemorrhage > 1500 mL who meet ROTEM point-of-case testing criteria for treatment with fibrinogen concentrate or placebo |
| FAST - Comparison of the probability of live birth after elective freezing of all embryos versus standard fresh embryo transfer in patients undergoing in-vitro fertilisation (IVF) | ACTRN12616000643471 | IVF Australia Southern Sydney, St George Private Hospital, NSW Dr Christos Venetis c.venetis@unsw.edu.au |
Not yet recruiting | Reproductive medicine, IVF fertilisation methods, embryo transfer | Women undergoing fertility treatment |
| The impact of pH on fertilisation in human oocytes | ACTRN12617000230358 | Westmead Fertility Centre; Westmead Hospital, Westmead NSW 2145 Dr Cecilia Sjoblom cecilia.sjoblom@sydney.edu.au |
Not yet recruiting | Reproductive medicine, IVF fertilisation methods | Women |
| Hominax for improving sperm health | ACTRN12616000194460 | National Institute of Complementary Medicine, Western Sydney University, Campbelltown Campus, Penrith NSW 2751 Prof Caroline Smith caroline.smith@westernsydney.edu.au |
Not yet recruiting | Reproductive medicine, infertility, male factor | Men undergoing fertility treatment |
| STREAM - Effect of ovarian stimulation on oocyte quality and embryonic aneuploidy: a prospective, randomised controlled trial | ACTRN12616001539426 | School of Women’s &, Children’s Health, Royal Hospital for Women, NSW 2031 Prof William Ledger w.ledger@unsw.edu.au |
Currently recruiting | Reproductive medicine, IVF, ovarian stimulation | Women undergoing fertility treatment |
| NIPA Trial (Nifedipine for improving Implantation and Pregnancy rates in ART) Does nifedipine improve implantation and pregnancy rates in women undergoing in-vitro fertilisation (IVF)/intracytoplasmic sperm injection (ICSI) cycles? | ACTRN12617000213347 | Melbourne IVF, East Melbourne, VIC, 3002 Dr Alex Polyakov alex.polyakov@mivf.com.au |
Currently recruiting | Reproductive medicine, IVF implantation, nifedipine | Women |
| PROVIDE - Impact of Protein IVN on Development: for extremely low birthweight babies, does higher intravenous protein intake in the first 5 days after birth improve neurodevelopmental outcome, growth and body composition through to 2 years of age? | ACTRN12612001084875 | Liggins Institute, University of Auckland, Barbara Cormack bcormack@adhb.govt.nz |
Currently recruiting
IMPACT reviewed
|
Protein, intravenous nutrition, neurodevelopment | Birthweight <1000 g |
| HUMBA - Healthy mUMs and Babies Trial. A four-armed randomised controlled demonstration trial of a multifaceted dietary intervention and probiotic capsules in obese pregnant women in the Counties Manukau Health region | ACTRN12615000400561 | HUMBA room, Community Midwifery area, Building2, Level 2, 19 Lambie Drive, Manukau, Auckland Contact: Rennae Taylor, Email: r.taylor@auckland.ac.nz |
Currently recruiting | Probiotics, Nutritional intervention, Birthweight, Gestational weight gain | Non-diabetic obese women with a singleton pregnancy |
| MPG Trial - Metformin in the Prevention of Gestational Diabetes | ACTRN12610000157077 | Women`s and Children`s Hospital, Children`s Youth and Women`s Health Service, North Adelaide suzette.coat@adelaide.edu.au | Discontinued | Prevention of recurrent Gestational diabetes | Women who have had a previous pregnancy affected by GDM |
| CHiPS Study - Weaning preterm infants with a gestational age (GA) of <30 weeks from respiratory support: a comparison of duration of respiratory support with heated humidified high flow nasal cannula (HHHFNC) and continuous positive airway pressure (CPAP) | ACTRN12615000077561 | Middlemore Hospital, Counties Manukau DHB, Neonatal Unit, Joanne Clements joanne.clements@middlemore.co.nz |
Currently recruiting | Preterm infants Weaning study High flow nasal cannula Continuous positive airway pressure (CPAP) |
Infants born at <30 weeks gestational age. Required to have been stable on CPAP 6cmH20 for at least 48 hours are eligible for study |
| PROTECT - Can Pentoxifylline improve long-term outcomes in preterm infants with late-onset sepsis or necrotizing enterocolitis? A pragmatic, randomized, controlled trial | ACTRN12616000405415 | NHMRC Clinical Trial Centre, NSW protect@ctc.usyd.edu.au |
Currently recruiting
IMPACT reviewed
|
Preterm infant sepsis and inflammation, neurodevelopment | Born at less than 29 weeks gestational age with suspected late-onset sepsis or necrotizing enterocolitis |
| Quad P-twins - Pessary or Progesterone to Prevent Preterm delivery in women with a twin pregnancy and short cervical length | ACTRN12616000875404 | The University of Adelaide, University Department of Obstetrics and Gynaecology, North Adelaide, SA 5006 Prof Ben Mol ben.mol@adelaide.edu.au |
Not yet recruiting | Preterm birth prevention, cervical pessary | Pregnant women, twins |
| ACTORDS - Australasian Collaborative Trial of Repeat Doses of Corticosteroids for the Prevention of Neonatal Respiratory Disease | ACTRN12606000318583; PT0349; ISRCTN48656428 | Adelaide Women's and Children's pat.ashwood@adelaide.edu.au |
Recruitment complete | Preterm birth improving outcomes (antenatal interventions). Newborn respiratory | Singleton, twin or triplet pregnancy at less than 32 weeks gestation; 7 or more days since first corticosteroid treatment, remaining at risk of preterm delivery |
| PROGRESS - Australian Collaborative trial of vaginal progesterone for prevention of neonatal respiratory distress syndrome | ISRCTN20269066; NHMRC399137 | Maternal Perinatal Clinical Trials Unit, Adelaide Women's and Children's Pat Ashwood | Recruitment complete | Preterm birth ? prevention and treatment. Preterm birth ? improving outcomes (antenatal interventions). Newborn respiratory | Pregnant women with a history of prior spontaneous preterm birth at less than 34 weeks gestation |
| ORIP - Omega-3 fats to reduce the incidence of prematurity | ACTRN12613001142729 | Women`s and Children`s Health Research Institute, SA (WCH) jo.zhou@adelaide.edu.au | Currently recruiting | Preterm birth ? prevention and treatment. Maternal nutrition | Women at less than 20 weeks' gestation |
| SMILE Study - Prevention of preterm birth by treatment of periodontal disease during pregnancy | NCT00133926/NHMRC353577 | ddoherty@obsgyn.uwa.edu.au | Recruitment complete | Preterm birth ? prevention and treatment | |
| CiPS - Candida in Pregnancy Study - Treatment of candidiasis to prevent preterm birth - pilot study CiPS pilot | ACTRN126090001052224 | Royal North Shore | Recruitment complete | Preterm birth ? prevention and treatment | |
| Cervical occlusion in women with cervical insufficiency: randomised, controlled trial with cerclage, with and without cervical occlusion | NCT01737788 | Recruitment complete | Preterm birth ? prevention and treatment | ||
| NIFTY - A multi-centre randomised double blind placebo controlled trial of nifedipine maintenance tocolysis in fetal fibronectin positive women in threatened preterm labour | ACTRN12613000985785 | National Women's Health, Auckland Hospital. Dr Emma Parry (Principal Investigator) EmmaP@adhb.govt.nz | Recruitment complete | Preterm birth ? prevention and treatment | Women with threatened preterm labour, a singleton pregnancy, gestational age between 24 and 34 weeks, intact membranes, positive fetal fibronectin test, completed course of corticosteroids |
| Improving oral hygiene to reduce the risk of preterm birth: A randomised controlled trial assessing a high intensity educational intervention | ACTRN12605000767606 | caroline.crowther@adelaide.edu.au | Discontinued | Preterm birth ? prevention and treatment | Women with a singleton pregnancy |
| A*STEROID - Australasian Antenatal Study to Evaluate the Role Of Intramuscular Dexamethasone versus betamethasone prior to preterm birth to increase survival free of childhood neurosensory disability - a randomised controlled trial | ACTRN12608000631303 | The University of Adelaide / Women's & Children's Hospital pat.ashwood@adelaide.edu.au | Recruitment complete | Preterm birth ? improving outcomes (antenatal interventions). Newborn respiratory | Women at risk of preterm birth at less than 34 weeks gestation, have a singleton or twin pregnancy and no contraindications to the use of antenatal corticosteroids |
| ACTOMgSO4 - Australasian Collaborative Trial of Magnesium Sulphate for the Prevention of Mortality and Cerebral Palsy in Infants Born Very Preterm | PT0354/ACTRN012606000252516 | Adelaide Women's and Children's caroline.crowther@adelaide.edu.au | Recruitment complete | Preterm birth ? improving outcomes (antenatal interventions) | Pregnant women of gestation less than 30 weeks where delivery is planned or definately expected within 24 hours |
| PPROMT - Immediate delivery vs expectant care in women with preterm prelabour rupture of the membranes close to term - A randomised clinical trial | PT0536/ISRCTN44485060/NHMRC358378 | Dept of Obstetrics & Gynaecology, Royal North Shore Hospital ppromt@med.usyd.edu.au | Recruitment complete | Preterm birth ? improving outcomes (antenatal interventions) | Singleton pregnancies, with confirmed ruptured membranes from 34 weeks to 36 weeks and 6 days gestation. |
| IRIS - A randomised clinical trial of different infusion rates of magnesium sulphate given prenatally to women for the prevention of side effects | ACTRN12605000765628 | Women's and Children's Hospital, SA caroline.crowther@adelaide.edu.au | Recruitment complete | Preterm birth ? improving outcomes (antenatal interventions) | Women at less than 30 weeks gestation where birth is planned or definitely expected within 24 hours. |
| PROMISE - The utility of predicting intrapartum fetal compromise at term using fetal cerebro-umbilical ratio and maternal placental growth factor | ACTRN12616001009404 | Mater Research Institute/University of Queensland, South Brisbane, QLD 4 Prof Sailesh Kumar sailesh.kumar@mater.uq.edu.au |
Not yet recruiting | Pregnancy, prediction, intrapartum fetal distress | Postnatal women |
| Efficacy of the Eating4Two smartphone application for the prevention of excessive gestational weight gain | ACTRN12617000169347 | University of Canberra, Bruce ACT, 2601 Prof Deborah Davis deborah.davis@canberra.edu.au |
Currently recruiting | Pregnancy, maternal weight gain, smart phone application | Pregnant women |
| ToBOGM - The Treatment Of BOoking Gestational diabetes Mellitus Study: Evaluating the impact on obstetric outcomes of immediate versus delayed care for gestational diabetes diagnosed at booking | ACTRN12616000924459 | Western Sydney University, School of Medicine, Campbelltown, NSW 2751 Prof David Simmons Da.Simmons@westernsydney.edu.au |
Not yet recruiting | Pregnancy, gestational diabetes | Pregnant women |
| ACTS - Australasian Collaborative Trial of vitamin C and E supplementation for the prevention of pre-eclampsia | ISRCTN00416244/NCT00097110/NHMRC207744 | caroline.crowther@adelaide.edu.au | Recruitment complete | Preeclampsia. Maternal nutrition. Maternal medical conditions | Nulliparous women with a singleton pregnancy, between 14-22 weeks gestation, a normal blood pressure |
| FRUIT-Study - Low-molecular-weight heparin added to aspirin in the prevention of recurrent early-onset pre-eclampsia in women with inheritable thrombophilia | ISRCTN87325378 | Department of Obstetrics and Gynaecology, VU University Medical Center, Amsterdam, Netherlands. Prof JIP de Vries (Chief Investigator) jip.devries@vumc.nl |
Recruitment complete | Preeclampsia. Fetal growth. Maternal medical conditions | women with previous pregnancy with hypertensive disease and/or SGA <34 weeks and an inheritable thrombophilia |
| TIPPS - Thrombophilia in pregnancy prophylaxis study: a multicentre, multinational, randomised controlled trial of prophylactic low molecular weight heparin in high-risk pregnant thrombophilic women | ISRCTN87441504 | The University of Ottawa Hospital, Ontario, Canada, Professor Marc Rodger (Chief Investigator). Suzette Coat - Australian Coordinator | Recruitment complete | Preeclampsia. Fetal growth | Pregnant women with thrombophilia at increased risk of venous thromboembolism or with previous placenta mediated pregnancy complication prior to 20 weeks gestation |
| HEPRIN - Heparin for the Prevention of complications related to placental Insufficiency | ISRCTN88675588 | Mt Sinai Hospital, Professor Jodie Dodd (Principal Investigator) jodie.dodd@adelaide.edu.u | Recruitment complete | Preeclampsia. Fetal growth | Women with significant risk factors for placental insufficiency (low PAPP-A, high AFP, high inhibin, high hCG, medical and obstetric risk factors or abdnormal uterine artery Doppler) |
| Folic Acid Clinic Trial (FACT) - Effect of folic acid supplementation in pregnancy on pre-eclampsia | ISRCTN23781770; NCT01355159 | Ottawa Health Research Institute, Ottawa, Canada bill.hague@adelaide.edu.au | Recruitment complete | Preeclampsia | |
| HOPE Trial - Prevention of recurrent pre-eclampsia by folic acid and supplementation in women with hyperhomocysteinaemia | PT0362 | William Hague | Recruitment complete | Preeclampsia | |
| A randomised controlled trial of dark chocolate in pregnancy for reduction in incidence of pre-eclampsia | ISRCTN41164968 | John James Medical Centre, Australian National University stephen.robson@anu.edu.au |
Recruitment complete | Preeclampsia | |
| Post partum haemorrhage (PPH) prevention: oxytocin pharmacokinetics and maternal body mass index (BMI) | ACTRN12617000176369 | Department of Obstetrics and Gynaecology, Monash University, Monash Medical Centre, Clayton, Victoria 3168 Prof Euan M. Wallace euan.wallace@monash.edu |
Not yet recruiting | Postpartum haemorrhage, prevention, pharmacokinetics | Birthing women |
| HUGS - Early intervention to protect the mother-infant relationship following postnatal depression - a randomised controlled trial | ACTRN12612001110875 | Parent-Infant Research Institute, Austin Health, (03) 9496 4496, piri@austin.org.au |
Recruitment complete | Postnatal depression, mother-infant interaction | Women aged 18 years or older with an infant aged 3-9 months and a clinical diagnosis of current major or minor depressive episode |
| Surgical transversus abdominis plane (TAP) blocks for post-operative pain relief following lower segment caesarean section (LSCS) under spinal anaesthesia | ACTRN12617000589381 | The Royal Women's Hospital, Victoria 3052 Dr James Griffiths jamesgriffiths@me.com |
Not yet recruiting | Post partum, pain management, caesarean section, surgical block | Birthing women |
| Evaluation of physiotherapy management in pregnancy related pelvic girdle pain | ACTRN12614000472673 | Westmead Hospital, Sydney NSW Australia. Ms Dragana Ceprnja dragana.ceprnja@health.nsw.gov.au | Currently recruiting | Pelvic girdle pain, physiotherapy | Pregnant women with pregnancy related pelvic girdle pain |
| Parenting from the start: Evaluating a preventative intervention to improve outcomes for first-time mothers and their babies | ACTRN12617000321347 | School of Psychology, Massey University Manawatu Campus, Palmerston North 4442, New Zealand Ms Leith Anna Pugmire l.pugmire@netmail.co.nz |
Not yet recruiting | Parenting support | Pregnant women |
| Evaluation of the C2u Project - Evaluation of the effectiveness of an infant and family health and wellbeing text message intervention (Connecting 2u) in supporting expectant and new parents | ACTRN12616000072415 | Children's Health Queensland, South Brisbane, QLD 4101 Ms Cindy Dawson Cindy.Dawson@health.qld.gov.au |
Currently recruiting | Parenting support | Pregnant women |
| Oxytocin as an adjunct to interaction coaching and baby massage to improve bonding in the early postpartum | ACTRN12609000483257 | The University of New South Wales rmcerlean@psy.unsw.edu.au | Currently recruiting | Parenting | |
| Effectiveness of a modified mother-infant transaction program on outcomes for preterm infants from 3 to 24 months of age | carol.newnham@austin.org.au | Recruitment complete | Parenting |